RT info:eu-repo/semantics/doctoralThesis
T1 Impact of Bioactive Compounds and Chemicals on the Management of Diseases Driven by Inflammation and Oxidative Stress
A1 Calvo Vecino, Hugo
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Inmunología
K1 Inflammation
K1 Inflamación
K1 Oxidative Stress
K1 Estrés Oxidativo
K1 Myocarditis
K1 Miocarditis
K1 Multiple Sclerosis
K1 Esclerosis Múltiple
K1 2412 Inmunología
AB Autoimmune diseases, such as myocarditis and multiple sclerosis, involve abnormal immune responses against the body’s own tissues, These conditions are associated with inflammation and oxidative stress, leading to progressive damage in affected organs. This study investigated the therapeutic potential of various compounds and natural extracts in preclinical models of these diseases. In an experimental autoimmune myocarditis (EAM) mouse model, the ability of the Hippo pathway inhibitor, XMU-MP-1, and the mitochondria-targeting peptide, Elamipretide (SS31), to modulate inflammatory responses and protect cardiac tissue was evaluated. In vitro experiments analyzed the protective effects of XMU-MP-1 and SS31 in cardiomyocites subjected to PA-BSA complex-induced stress. CoCl2 was also studied as an oxidative stress-inducing agent in these cells.Furthermore, the neuroprotective potential of Nectandra angustifolia extract was assessed in a mouse model of multiple sclerosis, the experimental autoimmune encephalomyelitis (EAE), focusing on clinical scores, immune responses, and neuroinflammation. Finally, the effects of olive pomace extracts, rich in bioactive compounds, were analyzed in retinal epithelial cells exposed to inflammatory and oxidative stress.The results of this study provide promising insights into how these agents could be used therapeutically to control autoimmune and neurodegenerative diseases affecting the heart, and central nervous system.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/80954
UL https://uvadoc.uva.es/handle/10324/80954
LA eng
NO Escuela de Doctorado
DS UVaDOC
RD 22-dic-2025