RT info:eu-repo/semantics/article
T1 Clinical tool to measure fluorescein patterns in orthokeratology
A1 López García Rosuero, Marina
A1 Arranz Bombín, Alejandro
A1 Romero Oraa, Roberto
A1 Hornero Sánchez, Roberto
A1 Martín Herranz, Raúl
K1 Optometria
K1 2209.15 Optometría
AB Background: Orthokeratology (ortho-k) is an overnight clinical contact lens wear technique to correct myopia and to reduce myopia progression wearing reverse-geometry rigid gas-permeable lenses. The lens fitting procedure in clinical practice usually requires subjective assessment of fluorescein pattern (fluorescein "bull's eye" pattern). The aim of this study was to develop a novel tool for fluorescein pattern measurements to reduce subjective practitioner dependency, especially in inexperienced practitioners, in ortho-k practice.Methods: A new MATLAB customized algorithm to measure the horizontal width of the four main zones of ortho-k fluorescein patterns (central bearing, tear reservoir, mid-peripheral bearing and edge lift) was designed. The algorithm was tested on a small image database consisting of 26 ortho-k fluorescein pattern images of 13 volunteers fitted with reverse geometry lenses (Seefree, Conoptica-Hecht Contactlinsen). The agreement between two independent observers and the ImageJ measurements was determined.Results: The new clinical tool provided similar measurements to ImageJ software for the central bearing (4.20 ± 0.74 and 4.27 ± 0.69 mm; P = 0.21), tear reservoir (1.69 ± 0.41 and 1.69 ± 0.45 mm; P = 0.69), mid-peripheral bearing (1.17 ± 0.11 and 1.13 ± 0.10 mm; P < 0.01) and edge lift (0.48 ± 0.06 and 0.48 ± 0.06 mm; P = 0.81) zones. Good agreement between the software (limits of agreement lower than ±0.55 mm) and inter-observer measurements (limits of agreement lower than ±0.66 mm) was found.Conclusions: The proposed clinical tool for semiautomatic fluorescein pattern measurements in ortho-k could help to reduce practitioner dependency in fluorescein pattern assessment with future potential to introduce prediction algorithms or artificial intelligence methods in myopia control management.
PB PeerJ
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/81035
UL https://uvadoc.uva.es/handle/10324/81035
LA spa
NO PeerJ. 2022; 23;10:e14068
DS UVaDOC
RD 15-feb-2026