RT info:eu-repo/semantics/article
T1 Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis
A1 Usategui-Martín, Ricardo
A1 Carbonell, Cristina
A1 Novo-Valeriro, Ignacio
A1 Hernández-Pinchete, Sara
A1 Mirón-Canelo, José Antonio
A1 Chamorro, Antonio Javier
A1 Marcos, Miguel
AB Background: Genetic predisposition plays an important role in the development of alcoholic pancreatitis (AP), with previous studies suggesting that genetics variants in certain genes, such asCYP2E1 and CTRC, partially explain individual susceptibility to this disease. Therefore, the aim of this work was to conduct a systematic review and meta-analysis of existing studies that analyzed how polymorphisms within CYP2E1 and CTRC genes influence the risk of AP.Material and methods: We performed a systematic review of studies that analyzed the genotype distribution of CYP2E1 and CTRC allelic variants among patients with AP and a group of controls. A meta-analysis was conducted using a random effects model. Odds ratios (ORs) and their confidence intervals (CIs) were calculated.Results: The T allele of theCTRC 180 C > T variant was significantly more prevalent among patients with AP compared to all controls (OR = 1.79, 95% CI = 1.43-2.24; P < 0.00001) and healthy subjects (OR = 1.84, 95% CI = 1.46-2.31; P < 0.00001). The Trp variant of CTRC Arg254Trp polymorphism was also more prevalent in patients with AP; however, these results were not significant after excluding one study. We found no clear evidence that CYP2E1-DraI or of CYP2E1-RsaI/PstI polymorphisms modulate the risk of developing AP.Conclusions: Our meta-analysis supports that the T allele ofCTRC 180C > T polymorphisms modulates the risk of alcoholic pancreatitis. No clear evidence was found for the remaining SNPs being associated with this disease.
PB ELSEVIER
SN 0376-8716
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/81598
UL https://uvadoc.uva.es/handle/10324/81598
LA spa
NO Drug Alcohol Depend  . 2020 Apr 1:209:107873
DS UVaDOC
RD 15-ene-2026