RT info:eu-repo/semantics/article
T1 The TP53 Arg72Pro polymorphism predicts visual and neurodegenerative outcomes in retinal detachment
A1 Galindo Cabello, Nadia Regina
A1 Sobas Abad, Eva María
A1 Rebeca, Lapresa
A1 Jesús, Agulla
A1 Angeles, Almeida
A1 Antonio, Lopez
A1 José Carlos, Pastor
A1 Pastor Idoate, Salvador
A1 Usategui Martín, Ricardo
AB Retinal detachment (RD) separates the retina from the retinal epithelium, causing photoreceptor apoptosis and irreversible visionloss. Even with successful surgical reattachment, complete visual recovery is not guaranteed. The TP53 Arg72Pro polymorphism,implicated in apoptosis, has emerged as a potential predictor of RD outcomes. We investigated the impact of the Arg72Propolymorphism on retinal neurodegeneration and functional recovery in patients. The underlying mechanisms were analyzed in ahumanized TP53 Arg72Pro RD mouse model. In a cohort of 180 patients, carriers of the Pro allele exhibited decreased apoptoticgene expression and improved visual recovery. Complementary findings in mice revealed that the Pro variant preservedphotoreceptor integrity and reduced apoptosis rates following RD. Our findings highlight the potential of this TP53 polymorphismas a biomarker for RD outcomes and a tool for tailoring therapies. This study underscores the importance of integrating geneticprofiling into personalized medicine approaches to improve recovery of RD patients’ visual outcomes
PB SPRINGERNATURE
SN 2041-4889
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/81615
UL https://uvadoc.uva.es/handle/10324/81615
LA spa
NO Cell Death Dis. 2025 May 26;16(1):415.
DS UVaDOC
RD 16-ene-2026