RT info:eu-repo/semantics/article
T1 Analysis of ATG4C function            in vivo
A1 Tamargo-Gómez, Isaac
A1 Martínez-García, Gemma G.
A1 Suárez, María F.
A1 Mayoral, Pablo
A1 Bretones, Gabriel
A1 Astudillo, Aurora
A1 Prieto-Lloret, Jesús
A1 Sveen, Christina
A1 Fueyo, Antonio
A1 Engedal, Nikolai
A1 López-Otín, Carlos
A1 Mariño, Guillermo
AB Despite the great advances in macroautophagy/autophagy research in the last years, the in vivo role of the different members of the four mammalian orthologs of yeast Atg4 protease (ATG4A-D) remain unclear. To gain further insights into the functional relevance of Atg4 orthologs, we have generated mutant mice deficient in Atg4c. These mice are viable and fertile, and do not display any obvious abnormalities, indicating that they are able to develop the autophagic response required during the early neonatal period. However, they show tissue-specific autophagy alterations, including reduced autophagic flux in diaphragm and show decreased breathing and locomotor activity after fasting. In addition, atg4c-/- mice show reduced number of circulating T and B lymphocytes, which is associated with accumulation of apoptotic cells in the spleen and an increased susceptibility to develop chemically-induced fibrosarcomas. Moreover, through the analysis of cells and mice simultaneously deficient for ATG4C and ATG4D proteases we also reveal a role for ATG4C in mATG8 proteins delipidation.
PB Taylor & Francis
SN 1554-8627
YR 2023
FD 2023-07-17
LK https://uvadoc.uva.es/handle/10324/81621
UL https://uvadoc.uva.es/handle/10324/81621
LA eng
NO Autophagy. 2023 Nov;19(11):2912-2933.
NO Producción Científica
DS UVaDOC
RD 16-ene-2026