RT info:eu-repo/semantics/article
T1 Heart rate variability as a potential biomarker of pediatric obstructive sleep apnea resolution
A1 Martín-Montero, Adrián
A1 Gutiérrez-Tobal, Gonzalo C
A1 Kheirandish-Gozal, Leila
A1 Vaquerizo-Villar, Fernando
A1 Álvarez, Daniel
A1 del Campo, Félix
A1 Gozal, David
A1 Hornero, Roberto
K1 3325 Tecnología de las Telecomunicaciones
K1 3314 Tecnología Médica
AB AbstractStudy ObjectivesPediatric obstructive sleep apnea (OSA) affects cardiac autonomic regulation, altering heart rate variability (HRV). Although changes in classical HRV parameters occur after OSA treatment, they have not been evaluated as reporters of OSA resolution. Specific frequency bands (named BW1, BW2, and BWRes) have been recently identified in OSA. We hypothesized that changes with treatment in these spectral bands can reliably identify changes in OSA severity and reflect OSA resolution.MethodsFour hundred and four OSA children (5–9.9 years) from the prospective Childhood Adenotonsillectomy Trial were included; 206 underwent early adenotonsillectomy (eAT), while 198 underwent watchful waiting with supportive care (WWSC). HRV changes from baseline to follow-up were computed for classical and OSA-related frequency bands. Causal mediation analysis was conducted to evaluate how treatment influences HRV through mediators such as OSA resolution and changes in disease severity. Disease resolution was initially assessed by considering only obstructive events, and was followed by adding central apneas to the analyses.ResultsTreatment, regardless of eAT or WWSC, affects HRV activity, mainly in the specific frequency band BW2 (0.028–0.074 Hz). Furthermore, only changes in BW2 were specifically attributable to all OSA resolution mediators. HRV activity in BW2 also showed statistically significant differences between resolved and non-resolved OSA.ConclusionsOSA treatment affects HRV activity in terms of change in severity and disease resolution, especially in OSA-related BW2 frequency band. This band allowed to differentiate HRV activity between children with and without resolution, so we propose BW2 as potential biomarker of pediatric OSA resolution.
PB Oxford University Press
SN 0161-8105
YR 2022
FD 2022-02
LK https://uvadoc.uva.es/handle/10324/81686
UL https://uvadoc.uva.es/handle/10324/81686
LA spa
NO Sleep, Mayo 2025, vo. 15, p.17574
NO Producción Científica
DS UVaDOC
RD 16-ene-2026