RT info:eu-repo/semantics/article
T1 Muscular Strength and Quality of Life in Older Adults: The Role of ACTN3 R577X Polymorphism
A1 Fernández-Araque, Ana
A1 Giaquinta-Aranda, Andrea
A1 Rodríguez-Díez, Jose Andrés
A1 Carretero-Molinero, Silvia
A1 López-López, Jorge
A1 Verde, Zoraida
AB As longevity is increasing, the 65-year-old and older population is projected to increase in the next decades, as are the consequences of age-related muscle deterioration on the quality of life. The purpose of this study was to examine the associations of the ACTN3R577X polymorphism with quality of life and muscular strength in an older Spanish population. In total, 281 older adults participated in this study. Anthropometric measurements, chronic diseases, prescribed medications, quality of life, hand grip strength, and physical activity and nutritional status data were collected. ACTN3 R577X genotyping was determined using Taqman probes. Multivariate regression analysis revealed in adjusted model that, in men, the ACTN3 R577X genotype was significantly associated with hand grip strength (HGS), regression coefficient (β) = 1.23, p = 0.008, dimension 1 of the five-dimension questionnaire EuroQoL (EQ-5D, mobility), (β) = -1.44, p = 0.006, and clinical group risk (CGR) category (β) = -1.38, p = 0.006. In women, a marginal association between the ACTN3 R577X genotype and the CGR category was observed, with a regression coefficient of (β) = -0.97, (p = 0.024). Our findings suggest that the ACTN3 R577X genotype may influence the decline in muscle strength and quality of life in older Spanish adult males.
PB MDPI
YR 2021
FD 2021-01-25
LK https://uvadoc.uva.es/handle/10324/81727
UL https://uvadoc.uva.es/handle/10324/81727
LA eng
NO Int J Environ Res Public Health . 2021 Jan 25;18(3):1055.
DS UVaDOC
RD 17-ene-2026