RT info:eu-repo/semantics/article
T1 Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain
A1 Grau-Perez, Maria
A1 Navas-Acien, Ana
A1 Galan-Chilet, Inmaculada
A1 Briongos-Figuero, Laisa S.
A1 Morchon-Simon, David
A1 Bermudez, Jose D.
A1 Crainiceanu, Ciprian M.
A1 de Marco, Griselda
A1 Rentero-Garrido, Pilar
A1 Garcia-Barrera, Tamara
A1 Gomez-Ariza, Jose L.
A1 Casasnovas, Jose A.
A1 Martin-Escudero, Juan C.
A1 Redon, Josep
A1 Chaves, F. Javier
A1 Tellez-Plaza, Maria
AB norganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric mean of total arsenic was 66.0 μg/g. The adjusted odds ratios (95% confidence interval) for diabetes comparing the highest with the lowest tertile of total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and after arsenobetaine adjustment, respectively. Polymorphisms in several genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive differential associations of urine total arsenic with diabetes. The findings support the role of arsenic on diabetes and the importance of controlling for seafood arsenicals in populations with high seafood intake. Suggestive arsenic-gene interactions require confirmation in larger studies.
SN 0269-7491
YR 2018
FD 2018-04
LK https://uvadoc.uva.es/handle/10324/81750
UL https://uvadoc.uva.es/handle/10324/81750
LA spa
NO Environ Pollut. 2018;235:948-955. doi:10.1016/j.envpol.2018.01.008
DS UVaDOC
RD 18-ene-2026