RT info:eu-repo/semantics/article
T1 Recent advances in microbial production of odd-chain fatty acids
A1 Timmers, Rudolphus Antonius
A1 Vicente Martínez, Marta de
A1 Rosa Masegosa, Aurora
A1 Romero, Elvira
A1 Tomás Pejó, Elia
A1 González Fernández, María Cristina
K1 Ingeniería metabólica
K1 Propionil-CoA:
K1 Biología sintética
K1 Ácidos grasos de cadena impar
K1 Fermentación microbiana
K1 Ácido propiónico
K1 Ácido pentanoico
K1 Ácido heptanoico
K1 Ácido pentadecanoico y ácido heptadecanoico
K1 Ingeniería genética
K1 2302.19 Procesos Metabólicos
K1 2414.07 Metabolismo Microbiano
K1 3302.90 Ingeniería Bioquímica
AB The production of odd-chain fatty acids (OCFAs) is gaining increasing importance due to their diverse applications in food, chemical, and biofuel industries. These fatty acids, which are relatively rare in nature, can be produced from renewable carbon sources through microbial fermentation processes. This review covers the significance of OCFAs in the market and their occurrence, followed by a detailed exploration of their production in mixed and single strain cultures. Specifically, the anaerobic fermentation (AF) conditions and feedstocks used to produce short OCFAs (SOCFAs), such as propionic, valeric, and heptanoic acids are discussed. Additionally, the production of long OCFAs (LOCFAs) by single strains is focusing on yeast, bacteria, and microalgae. Novel approaches for LOCFAs generation from waste carbon sources are also reviewed. This work delves both into the manipulation of microbial communities covering bioaugmentation and process optimization for bioenrichment in open mixed cultures and genetic manipulation in single-strain systems. Finally, the potential for scalable and sustainable production of OCFAs through microbial processes is discussed, as well as the technological advances needed to optimize these pathways.
PB Springer Nature
SN 0959-3993
YR 2026
FD 2026
LK https://uvadoc.uva.es/handle/10324/81898
UL https://uvadoc.uva.es/handle/10324/81898
LA eng
NO World Journal of Microbiology and Biotechnology, 2026, vol 42, n. 40.
NO Producción Científica
DS UVaDOC
RD 21-ene-2026