RT info:eu-repo/semantics/doctoralThesis
T1 Human Intestinal immune and microbial signatures in Inflammatory Bowel Disease: A multidisciplinary approach to disease mechanisms
A1 Arribas Rodríguez, Elisa
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Enfermedad Inflamatoria Intestinal
K1 Immunology
K1 Inmunología
K1 Dendritic cells
K1 Células dendríticas
K1 Crohn's Disease
K1 Enfermedad de Crohn
K1 Ulcerative colitis
K1 Colitis ulcerosa
K1 32 Ciencias Médicas
AB This thesis was aimed to deepen our understanding of the key factors underlying IBD, focusing primarily on the study of two main factors underlying IBD: immunome and microbiota. Regarding the immunome, I focused on APCs, as they are crucial regulators of intestinal homeostasis. In particular, cDCs play a pivotal role in shaping the type of response elicited against antigens (tolerogenic against commensals and inflammatory against pathogens, in health conditions), which led us to hypothesize that they may also be therapeutic targets of some drugs (specifically tofacitinib), used in IBD treatment (UC in this case). Furthermore, given the importance of the gut microbiota in maintaining intestinal homeostasis and its involvement in IBD pathogenesis, this thesis also aimed to characterize the faecal and intestinal mucosal-associated microbiome in human samples, with the final goal of identifying bacterial and fungal patterns and potential faecal biomarkers.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/81908
UL https://uvadoc.uva.es/handle/10324/81908
LA eng
NO Escuela de Doctorado
DS UVaDOC
RD 21-ene-2026