RT info:eu-repo/semantics/article
T1 Tear Cytokines as Predictive Biomarkers of Success in Contact Lens Discomfort Management
A1 Valencia-Nieto, Laura
A1 García-Vázquez, Carmen
A1 Fernández, Itziar
A1 Calderón García, Andrés Ángel
A1 López De La Rosa, Alberto
A1 López Miguel, Alberto
A1 Arroyo del Arroyo, Cristina
A1 Blanco Vázquez, Marta
A1 Novo Díez, Andrea
A1 Enriquez De Salamanca Aladro, Amalia
A1 González García, María Jesús
K1 Lentes de contacto
K1 Oftalmología
K1 Biomarcador
K1 Lentes de contacto
K1 Incomodidad
K1 Inflamación
K1 Citoquina
K1 3201.09 Oftalmología
AB PurposeTo analyze changes in tear levels of inflammatory mediators in symptomatic contact lens (CL) wearers after refitting with daily disposable CLs and to identify potential biomarkers of success in CL discomfort (CLD) management.MethodsSymptomatic CL wearers (CLDEQ-8 ≥ 12) were refitted (V1) with daily disposable CLs (Delefilcon A). After one month (V2), participants were classified into the post-fitting non-symptomatic (CLDEQ <12) and symptomatic (CLDEQ ≥12) groups. At each visit, the participants were clinically evaluated, tears were collected, and 20 inflammatory mediators and substance P (SP) were measured using multiplex immunobead analysis and ELISA, respectively. The detection rates and concentrations were compared between visits and groups, and logistic regression models were performed.ResultsForty-three subjects (32 women/11 men; mean age: 23.2 ± 4.9 years) were enrolled. The IL-1β and IL-9 detection rates were higher at V2 (p ≤ 0.044). The detection rates of IL-1β, IL-9, MIP-1α/CCL3, and MMP-9 at V1 (p ≤ 0.045) and IL-17A at V2 (p ≤ 0.014) were higher in the post-fitting symptomatic group. The tear IL-9 concentration was increased at V2 (p = 0.018). The tear concentrations of fractalkine/CX3CL1, IL-2, IL-6, IL-10, MCP-3/CCL7, MIP-1β, NGF, RANTES/CCL5, and TNF-α were higher in the post-fitting symptomatic group (p ≤ 0.044). Additionally, levels of fractalkine/CX3CL1, IL-2, IL-6, IL-10, RANTES/CCL5, and TNF-α at V1 were significantly associated with the post-fitting grouping (p ≤ 0.044).ConclusionsLow tear concentrations of specific inflammatory mediators may be used as a predictive biomarker of success for refitting symptomatic CL wearers with daily disposable CLs. However, complementary treatments might be required for symptomatic CL wearers with higher levels of these inflammatory molecules.
PB TAYLOR & FRANCIS INC
SN 0927-3948
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/81954
UL https://uvadoc.uva.es/handle/10324/81954
LA eng
NO Ocular Immunology and Inflammation, 2024, Vol. 32, Núm. 10, pp. 2339-2347
NO Producción Científica
DS UVaDOC
RD 22-ene-2026