RT info:eu-repo/semantics/article
T1 Correlations Between Disability Score, Optical Coherence Tomography and Microperimetry in Patients with Multiple Sclerosis
A1 Guantay, Carla Daniela
A1 Mena García, Laura
A1 Tola Arribas, Miguel Ángel
A1 Garea García-Malvar, María José
A1 Yugueros Fernández, María
A1 Mayo Iscar, Agustín
A1 Pastor Jimeno, José Carlos
K1 Oftalmología
K1 ocular movement anomalies
K1 expanded disability status scale
K1 neurodegenerative diseases
K1 fixation instability
K1 retinal sensitivity
K1 3201.09 Oftalmología
K1 3207 Patología
AB Purpose: To characterize ocular motility disturbances through Microperimetry (MP) in patients with Multiple Sclerosis (MS) trying to detect those capable of influencing the disability to improve the accuracy of assessing visual impact in EDSS scale. MP results were compare with some structural parameters obtained by OCT.Patients and methods: Cross-sectional analytical and correlational case-control study approved by Ethical Committee. A total of 82 eyes (41 patients) and 30 healthy eyes (15 subjects) were enrolled after informed consent. All participants underwent ophthalmological evaluation with MP and OCT. Variables included MS disease duration, Expanded Disability Status Scale (EDSS) score; in OCT: central macular thickness (CMT), ganglion cell-inner plexiform layer thickness (GCIPL), and peripapillary retinal nerve fiber layer thickness (pRNFL); and in MP: test duration, reaction time, average macular threshold (AT), and 4 fixation stability indexes (P1, P2, BCEA63, BCEA95).Results: MS group showed a significant decrease in GCIPL (p < 0.001) and pRNFL thickness (p < 0.001) compared to the control group. Furthermore, patients demonstrated a longer examination (p < 0.001) and reaction (p < 0.001) times, reduced AT (p < 0.001), more unstable fixation indexes (P1 p <0.004, P2 p = 0.018, BCEA63 p = 0.005 and BCEA95 p = 0.007), measured by MP. In addition, patients with a history of ON (n=16) demonstrated longer examination times in MP (p = 0.049) compared to MS patients without ON, but they were not correlations with OCT measurements, EDSS score correlated with the CMT (p = 0.023, r = -0.25), MP duration (p = 0.043, r = 0.22), and fixation indexes (P1 p = 0.049, r = -0.22, BCEA63 p = 0.041, r = 0.23, BCEA95 p = 0.049, r = 0.22).Conclusion: Our study emphasizes the complementary utility of MP and OCT in assessing MS patients. Additionally, it highlights that using MP for objective measurements of oculomotor dysfunction could improves accuracy in disability assessment on the EDSS scale.
PB DovePress. Taylor & Francis
SN 1179-2744
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/82133
UL https://uvadoc.uva.es/handle/10324/82133
LA eng
NO Carla D Guantay, Laura Mena-García, Miguel Ángel Tola-Arribas, María José Garea García-Malvar, María Isabel Yugueros Fernández, Agustín Mayo-Iscar & José Carlos Pastor (2024) Correlations Between Disability Score, Optical Coherence Tomography and Microperimetry in Patients with Multiple Sclerosis, Eye and Brain, , 89-100, DOI: 10.2147/ EB.S469182
NO Producción Científica
DS UVaDOC
RD 27-feb-2026