RT info:eu-repo/semantics/article
T1 Distinct cortical inhibitory profiles in schizophrenia and bipolar disorder: A TMS-EEG study of GABAb function
A1 Mijancos Martínez, Gema
A1 Fernández Linsenbarth, Ines
A1 Bachiller Matarranz, Alejandro
A1 Beño Ruiz De La Sierra, Rosa María
A1 Osorio Iriarte, María Emma
A1 Roig Herrero, Alejandro
A1 Rodríguez Valbuena, Claudia
A1 Fiorini Talavera, Juan Carlos
A1 Ruiz Gómez, Saúl José
A1 Mancha, Ricardo D.
A1 Molina Rodríguez, Vicente
A1 Mañanas, Miguel Ángel
K1 LICI
K1 Schizophrenia
K1 GABA
K1 Transcranial
K1 Stimulation
K1 32 Ciencias Médicas
AB Background: EEG recordings associated with transcranial magnetic stimulation (TMS) with paired pulse para-digms allow the in vivo assessment of cortical inhibitory function. The long-interval cortical inhibition (LICI)paradigm can be used to estimate this function related to GABAb receptors.Methods: We compared LICI values between 25 patients with schizophrenia, 16 patients with bipolar disorder(BD), and 23 healthy controls (HC). We also assessed the relationship between LICI values and cognitive per-formance, as well as the treatment with antipsychotics, benzodiazepines, and anticonvulsants.Results: LICI was significantly lower in patients with schizophrenia than in controls, but not in BD patients. In theformer group, LICI was negatively associated with cognitive performance and positive symptoms. However,benzodiazepines increased LICI values, which does not explain its decrease in schizophrenia patients.Conclusions: Our data support the existence of a functional inhibitory deficit mediated by GABAb receptors inschizophrenia, that is associated with cognitive performance and symptoms. In the context of existing literature,this deficit may characterize a subgroup of patients with this diagnosis
PB Elsevier
SN 0278-5846
YR 2026
FD 2026
LK https://uvadoc.uva.es/handle/10324/82486
UL https://uvadoc.uva.es/handle/10324/82486
LA eng
NO Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026, vol. 144, p. 111593
NO Producción Científica
DS UVaDOC
RD 26-feb-2026