RT info:eu-repo/semantics/article
T1 Cytokine profiles linked to fatal outcome in infective prosthetic valve endocarditis
A1 Bustamante, Juan
A1 Arévalo, Adolfo
A1 Tamayo, Eduardo
A1 Sarria, Cristina
A1 Aguilar‐Blanco, Eva M.
A1 Heredia, Maria
A1 Almansa, Raquel
A1 Rico, Lucia
A1 Iglesias, Verónica
A1 Bermejo‐Martin, Jesús F
K1 Infective; cytokines; endocarditis; mortality; prosthetic
AB Infective endocarditis is a disease normally of bacterial cause which affects the endocardic tissue, specifically the valves (native or prosthetic). It is a serious illness and mortality rates remain high, ranging between 20% and 40%. Previous reports have evidenced the potential role of cytokines in the diagnosis of this disease, but no information is available on their relationship with outcome. We recruited 26 consecutive patients with late prosthetic valve endocarditis requiring surgical treatment according to Duke criteria. Eight cytokines were measured in plasma in the first 24 h following diagnosis by using a Bio-Rad multiplex assay. Levels of IL-6, IL-8 and interferon gamma (IFN-γ) were higher in non survivors. Receiver operating characteristic curve analysis evidenced that IL-6, IL-8 and IFN-γ behaved as good diagnostic tests for identifying those patients with fatal outcome (area under the curve, CI 95%, p): IL-6: [0.81 (0.61-1.00) 0.012]; IL-8 [0.76 (0.56-0.96) 0.035]; IFN-γ [0.79 (0.59-0.99) 0.021]. Levels of IL-6, IL-8 and IFN-γ correlated positively between them, indicating that they are produced as consequence of a simultaneous response to the infection. Our findings support the participation of IL-6, IL-8 and IFN-γ in the events linked to fatal outcome in infective prosthetic valve endocarditis
PB Wiley
SN 0903-4641
YR 2013
FD 2013
LK https://uvadoc.uva.es/handle/10324/82580
UL https://uvadoc.uva.es/handle/10324/82580
LA eng
NO Bustamante, J., Arévalo, A., Tamayo, E., Sarria, C., Aguilar-Blanco, E. M., Heredia, M., Almansa, R., Rico, L., Iglesias, V., & Bermejo-Martin, J. F. (2014). Cytokine profiles linked to fatal outcome in infective prosthetic valve endocarditis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(6), 526–529. https://doi.org/10.1111/apm.12189
NO Producción Científica
DS UVaDOC
RD 05-feb-2026