RT info:eu-repo/semantics/article
T1 Procalcitonin cannot be used as a biomarker of infection in heart surgery patients with acute kidney injury
A1 Heredia-Rodríguez, María
A1 Bustamante-Munguira, Juan
A1 Fierro, Inmaculada
A1 Lorenzo, Mario
A1 Jorge-Monjas, Pablo
A1 Gómez-Sánchez, Esther
A1 Álvarez, Francisco J.
A1 Bergese, Sergio D.
A1 Eiros, José María
A1 Bermejo-Martin, Jesús F.
A1 Gómez-Herreras, José I.
A1 Tamayo, Eduardo
K1 Acute kidney injury; Cardiac surgery; Infection; Inflammatory response; Postoperative care; Renal function failure
AB Purpose: We intended to assess how acute kidney injuy impacts on procalcitonin levels in cardiac surgery patients, with or without infection, and whether procalcitonin might be used as a biomarker of infection in acute kidney injuy.Material and methods: A case-control study was designed which included patients that had had cardiac surgery between January 2011 and January 2015. Every patient developing severe sepsis or septic shock (n = 122; 5.5%) was enrolled. In addition, consecutive cardiac surgery patients during 2013 developing systemic inflammatory response syndrome (n = 318) were enrolled. Those recruited 440 patients were divided into 2 groups, according to renal function.Results: Median procalcitonin levels were significantly higher during the 10 postoperative days in the acute kidney injury patients. Regression analysis showed that postoperatory day, creatinine, white blood cells and infection were significantly (P < .0001) associated to serum procalcitonin level. In patients with creatinine ≥2, median procalcitonin levels were similar in infected and non-infected patients. Only when creatinine was less than 2 mg/L, the median procalcitonin levels were significantly higher in patients with infection, as compared to those with no infection.Conclusions: In acute kidney injuy patients, high procalcitonin levels are a marker of acute kidney injuy but will not be able to differentiate infected from non-infected patients
PB Elsevier Inc.
SN 0883-9441
YR 2016
FD 2016
LK https://uvadoc.uva.es/handle/10324/82638
UL https://uvadoc.uva.es/handle/10324/82638
LA eng
NO Heredia-Rodríguez, M., Bustamante-Munguira, J., Fierro, I., Lorenzo, M., Jorge-Monjas, P., Gómez-Sánchez, E., Álvarez, F. J., Bergese, S. D., Eiros, J. M., Bermejo-Martin, J. F., Gómez-Herreras, J. I., & Tamayo, E. (2016). Procalcitonin cannot be used as a biomarker of infection in heart surgery patients with acute kidney injury. Journal of critical care, 33, 233–239. https://doi.org/10.1016/j.jcrc.2016.01.015
NO Producción Científica
DS UVaDOC
RD 07-feb-2026