RT info:eu-repo/semantics/article
T1 Overcoming Rest–Task Divide—Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia
A1 Northoff, Georg
A1 Gomez-Pilar, Javier
AB Schizophrenia is a complex psychiatric disorder exhibiting alterations in spontaneous and task-related cerebral activity whose relation (termed “state dependence”) remains unclear. For unraveling their relationship, we review recent electroencephalographic (and a few functional magnetic resonance imaging) studies in schizophrenia that assess and compare both rest/prestimulus and task states, ie, rest/prestimulus–task modulation. Results report reduced neural differentiation of task-related activity from rest/prestimulus activity across different regions, neural measures, cognitive domains, and imaging modalities. Together, the findings show reduced rest/prestimulus–task modulation, which is mediated by abnormal temporospatial dynamics of the spontaneous activity. Abnormal temporospatial dynamics, in turn, may lead to abnormal prediction, ie, predictive coding, which mediates cognitive changes and psychopathological symptoms, including confusion of internally and externally oriented cognition. In conclusion, reduced rest/prestimulus–task modulation in schizophrenia provides novel insight into the neuronal mechanisms that connect task-related changes to cognitive abnormalities and psychopathological symptoms.
PB Oxford University Press (OUP)
SN 0586-7614
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/82748
UL https://uvadoc.uva.es/handle/10324/82748
LA spa
NO G. Northoff y J. Gomez-Pilar, Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia, Schizophrenia Bulletin, vol. 47, n.º 3, pp. 751-765, 2021, doi: 10.1093/SCHBUL/SBAA178
DS UVaDOC
RD 13-feb-2026