RT info:eu-repo/semantics/article
T1 Altered brain dynamics index levels of arousal in complete locked-in syndrome
A1 Zilio, Federico
A1 Gomez-Pilar, Javier
A1 Chaudhary, Ujwal
A1 Fogel, Stuart
A1 Fomina, Tatiana
A1 Synofzik, Matthis
A1 Schöls, Ludger
A1 Cao, Shumei
A1 Zhang, Jun
A1 Huang, Zirui
A1 Birbaumer, Niels
A1 Northoff, Georg
AB Complete locked-in syndrome (CLIS) resulting from late-stage amyotrophic lateral sclerosis (ALS) is characterised by loss of motor function and eye movements. The absence of behavioural indicators of consciousness makes the search for neuronal correlates as possible biomarkers clinically and ethically urgent. EEG-based measures of brain dynamics such as power-law exponent (PLE) and Lempel-Ziv complexity (LZC) have been shown to have explanatory power for consciousness and may provide such neuronal indices for patients with CLIS. Here, we validated PLE and LZC (calculated in a dynamic way) as benchmarks of a wide range of arousal states across different reference states of consciousness (e.g., awake, sleep stages, ketamine, sevoflurane). We show a tendency toward high PLE and low LZC, with high intra-subject fluctuations and inter-subject variability in a cohort of CLIS patients with values graded along different arousal states as in our reference data sets. In conclusion, changes in brain dynamics indicate altered arousal in CLIS. Specifically, PLE and LZC are potentially relevant biomarkers to identify or diagnose the arousal level in CLIS and to determine the optimal time point for treatment, including communication attempts.
PB Springer Nature
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/82758
UL https://uvadoc.uva.es/handle/10324/82758
LA eng
NO F. Zilio, J. Gomez-Pilar, et al. Altered brain dynamics index levels of arousal in complete locked-in syndrome, Communications Biology, vol. 6, n.º 1, 2023, doi: 10.1038/S42003-023-05109-1
DS UVaDOC
RD 29-mar-2026