RT info:eu-repo/semantics/article T1 Screening of antiviral activity in freshwater and marine microalgae: Inactivation capacity over enveloped and non-enveloped viruses A1 León Vaz, Antonio A1 Tejero Álvarez, Lucía A1 García Encina, Pedro Antonio A1 Muñoz Torre, Raúl A1 Torres Franco, Andrés Felipe K1 Bacteriophage K1 Chlorella vulgaris K1 MS2 K1 Phi6 K1 PhiX174 K1 Thalassiosira weissflogii K1 Viral inactivation K1 3308 Ingeniería y Tecnología del Medio Ambiente AB New viruses are one of the major health challenges that human society is facing during this century. One of themost promising solutions is searching for natural organisms or molecules with antiviral capacity, with emergingmicroalgae as a promising solution in recent years. Thus, in this work, the antiviral capacity of ten species offreshwater and marine microalgae was tested against three enveloped and non-enveloped bacteriophages(PhiX174, MS2 and Phi6), showing inhibition efficiencies ranging from 40 to 80% compared with control in-fections. Moreover, the PCA analysis revealed the influence of the microalgal cell wall on the different bacte-riophages’ inactivation capacity. Finally, the inactivation of the three bacteriophages in liquid cultures wasstudied using the microalgae Chlorella vulgaris and Thalassiosira weissflogii. These microalgae inactivated99.999% of the MS2 and Phi6, and 99.9% of PhiX174 after 72 h of cultivation, respectively. Additionally, T90values ranging from 7 to 12 h for PhiX174, 3 to 12 h for MS2 and 2.5 to 3 h for Phi6 were achieved by the twotested microalgae. These results highlight the potential of microalgae for the inactivation of viruses in waste-waters and as an outstanding source of antivirals. PB Elsevier SN 0301-4797 YR 2026 FD 2026 LK https://uvadoc.uva.es/handle/10324/82810 UL https://uvadoc.uva.es/handle/10324/82810 LA eng NO Journal of Environmental Management, 2026, vol. 401, p. 128879 NO Producción Científica DS UVaDOC RD 17-feb-2026