RT info:eu-repo/semantics/article
T1 Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors
A1 Tamayo-Gómez, Eduardo
A1 Gómez, Esther
A1 Bustamante, Juan
A1 Gómez-Herreras, José Ignacio
A1 Fonteriz, Rosalba
A1 Bobillo, Felipe
A1 Bermejo-Martín, Jesús F
A1 Castrodeza, Javier
A1 Heredia, María
A1 Fierro, Inma
A1 Álvarez, Francisco Javier
K1 Apoptosis
K1 Neutrophil
K1 Septic shock
K1 Mortality
K1 Survivors
AB Purpose: The aims were to analyze the temporal evolution of neutrophil apoptosis, to determine thedifferences in neutrophil apoptosis among 28-day survivors and nonsurvivors, and to evaluate the use ofneutrophil apoptosis as a predictor of mortality in patients with septic shock.Materials and Methods: Prospective multicenter observational study carried out between July 2006 andJune 2009. The staining solution study included 80 patients with septic shock and 25 healthy volunteers.Neutrophil apoptosis was assessed by fluorescein isothiocyanate (FITC)–conjugated annexin V andaminoactinomycin D staining.Results: The percentage of neutrophil apoptosis was significantly decreased at 24 hours, 5 days, and 12days after the diagnosis of septic shock (14.8% ± 13.4%, 13.4% ± 8.4%, and 15.4% ± 12.8%, respectively;P b .0001) compared with the control group (37.6% ± 12.8%). The difference in apoptosis between 28-daysurviving and nonsurviving patients was nonsignificant (P N .05). The mortality rate at 28 days was 53.7%.The crude hazard ratio for mortality in patients with septic shock did not differ according to the percentage of apoptosis (hazard ratio, 1.006; 95% confidence interval, 0.98-1.03; P = .60).Conclusions: During the first 12 days of septic shock development, the level of neutrophil apoptosisdecreases and does not recover normal values. No differences were observed between surviving andnonsurviving patients.
SN 0883-9441
YR 2012
FD 2012
LK https://uvadoc.uva.es/handle/10324/82888
UL https://uvadoc.uva.es/handle/10324/82888
LA spa
NO J Crit Care, 2012, Aug; 27(4):415.e1-11.
NO Producción Científica
DS UVaDOC
RD 22-feb-2026