RT info:eu-repo/semantics/article
T1 Transcriptomic correlates of organ failure extent in sepsis
A1 Almansa, Raquel
A1 Heredia-Rodríguez, María
A1 Gómez-Sánchez, Esther
A1 Andaluz-Ojeda, David
A1 Iglesias, Verónica
A1 Rico, Lucía
A1 Ortega, Alicia
A1 Gómez-Pesquera, Estefanía
A1 Pilar, Liu
A1 Aragón, Marta
A1 Eiros, José María
A1 Jiménez-Sousa, María Ángeles
A1 Resino, Salvador
A1 Gómez-Herreras, Ignacio
A1 Bermejo-Martín, Jesús F
A1 Tamayo, Eduardo
K1 Organ failure extent; SOFA; Immune response; Immunosuppresion; Microarrays
AB Objectives: Sepsis is characterised by the frequent presence of organ failure andmarked immunologic alterations. We studied the association between the extent of organ failureand the transcriptomic response of septic patients.Methods: Gene expression profiles in the blood of 74 surgical patients with sepsis were compared with those of 30 surgical patients with no sepsis. Differentially expressed genes were assessed for their correlation with the sequential organ failure (SOFA) score.Results: The expression levels of a group of genes participating in the cell cycle (HIST1H1C,CKS2, CCNA2, CDK1, CCNB2, CIT, CCNB1, AURKA, RAD51), neutrophil protease activity (ELANE,ADORA3, MPO, MMP8, CTSG), IL-1R and IL-18R response correlated directly with SOFA and mortality.Genes involved in T cell (LCK, CD3G, CD3D, ZAP70, ICOS, CD3E, CD28, IL2RB, CD8B,CD8A, CD40LG, IL23A, CCL5, SH2D1A, ITK, CD247, TBX21, GATA3, CCR7, LEF1, STAT4) andNK cell immunity (CD244, KLRK1, KLRD1) were inversely associated with SOFA and mortality.Conclusions: The extent of organ failure in sepsis correlates directly with the existence ofimbalanced innate and adaptive responses at the transcriptomic level. Quantification of theexpression levels of the genes identified here could contribute to the simultaneous assessmentof disease severity and immunological alterations in sepsis.
PB W B SAUNDERS CO LTD
SN 0163-4453
YR 2014
FD 2014
LK https://uvadoc.uva.es/handle/10324/82890
UL https://uvadoc.uva.es/handle/10324/82890
LA spa
NO J Infect,2015 May;70(5):445-56
NO Producción Científica
DS UVaDOC
RD 22-feb-2026