RT info:eu-repo/semantics/article
T1 Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery
A1 Jiménez-Sousa, Maria Angeles
A1 Tamayo, Eduardo
A1 Guzmán-Fulgencio, María
A1 Heredia, María
A1 Fernández-Rodríguez, Amanda
A1 Gómez, Esther
A1 Almansa, Raquel
A1 Gómez-Herreras, José I.
A1 García-Álvarez, Mónica
A1 Gutiérrez-Junco, Sandra
A1 Bermejo-Martin, Jesús F.
A1 Resino, Salvador
K1 Mitochondrial haplogroups; Severe sepsis; Systemic Inflammatory Response Syndrome
AB Objective: To analyse whether mitochondrial DNA (mtDNA) haplogroups are associatedwith severe sepsis and mortality after major surgery.Methods: We performed a case-control study on 240 cardiac or abdominal surgery patientsdeveloping severe sepsis (Case-group) and 267 cardiac or abdominal surgery patients withoutsevere sepsis and with systemic inflammatory response syndrome (SIRS, Control-group).Furthermore, a longitudinal substudy was performed for analysing the survival in septic patients.Only European white patients within the N macro-cluster were included.Results: Case-group underwent cardiac surgery had lower frequencies of cluster HV(p Z 0.005) and haplogroup H (p Z 0.005) and higher frequencies of cluster JT (p Z 0.028)than Control-group; but no significant differences were found for abdominal surgery. Besidesboth cluster HV and haplogroup H were associated with decreased odds of severe sepsis(adjusted odds ratio (aOR) Z 0.45 (95%CI Z 0.25; 0.82); p Z 0.009 and aOR Z 0.48 (95%CI Z 0.26; 0.87); p Z 0.015, respectively) among patients underwent cardiac surgery. InCase-group, 45.4% (109/240) patients died with a survival median of 39 (95%CI Z 31.4;46.62) days. When the clusters were examined, 41% (55/134) patients within cluster HV diedversus 71.4% (10/14) patients within cluster IWX (p Z 0.018). Additionally, patients withincluster IWX had an increased risk of death (adjusted hazard ratio (aHR) Z 2.22; (95%CI Z 1.14; 4.34); p Z 0.019).Conclusions: European mitochondrial haplogroups might be related to the onset of severesepsis in patients who underwent major cardiac surgery, but not in patients underwent majorabdominal surgery. Besides, mtDNA haplogroups could have influence on mortality in septic patients.
PB W B SAUNDERS CO
SN 0163-4453
YR 2015
FD 2015
LK https://uvadoc.uva.es/handle/10324/82891
UL https://uvadoc.uva.es/handle/10324/82891
LA spa
NO J Infect,2015 Jan;70(1):20-9
NO Producción Científica
DS UVaDOC
RD 22-feb-2026