RT info:eu-repo/semantics/article
T1 Lipid-Binding Proteins in Brain Health and Disease
A1 Corraliza Gómez, Miriam
A1 Sánchez Romero, Diego
A1 Ganfornina Álvarez, María Dolores
K1 Bioquímica
K1 Neurodegeneración
K1 barrera hematoencefálica
K1 transporte de lípidos
K1 estrés oxidativo
K1 neuroinflamación
K1 amiloidogénesis
K1 neurodegeneración
K1 desmielinización
K1 trastorno de almacenamiento lisosomal
K1 2302 Bioquímica
K1 2490.02 Neuroquímica
AB A proper lipid management is paramount for a healthy brain. Lipid homeostasis alterations are known to be causative or risk factors for many neurodegenerative diseases, or key elements in the recovery from nervous system injuries of different etiology. In addition to lipid biogenesis and catabolism, non-enzymatic lipid-binding proteins play an important role in brain function and maintenance through aging. Among these types of lipoproteins, apolipoprotein E has received much attention due to the relationship of particular alleles of its gene with the risk and progression of Alzheimer's disease. However, other lipid-binding proteins whose role in lipid homeostasis and control are less known need to be brought to the attention of both researchers and clinicians. The aim of this review is to cover the knowledge of lipid-managing proteins in the brain, with particular attention to new candidates to be relevant for brain function and health.
PB Frontiers
SN 1664-2295
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/82919
UL https://uvadoc.uva.es/handle/10324/82919
LA eng
NO Frontiers in Neurology, 2019, vol. 10, p. 1-15.
NO Producción Científica
DS UVaDOC
RD 24-feb-2026