RT info:eu-repo/semantics/article
T1 Modulation of Glial Responses by Furanocembranolides: Leptolide Diminishes Microglial Inflammation in Vitro and Ameliorates Gliosis In Vivo in a Mouse Model of Obesity and Insulin Resistance
A1 Corraliza Gómez, Miriam
A1 Gallardo, Amalia B.
A1 Díaz Marrero, Ana R.
A1 de la Rosa, José M.
A1 D'Croz, Luis
A1 Darias, José
A1 Arranz Sanz, Eduardo
A1 Cózar Castellano, Irene
A1 Ganfornina Álvarez, María Dolores
A1 Cueto, Mercedes
K1 Biología molecular
K1 Bioquímica
K1 Enfermedades metabólicas
K1 Leptogorgia
K1 furanocembranolidas
K1 leptolida
K1 microglia
K1 astrocitos
K1 gliosis
K1 compuestos antiinflamatorios
K1 productos naturales bioactivos
K1 descubrimiento de fármacos
K1 dieta alta en grasas
K1 2403 Bioquímica
K1 2411.12 Fisiología del Sistema Nervioso Central
K1 2411.11 Neurofisiología
AB Neurodegenerative diseases are age-related disorders caused by progressive neuronal death in different regions of the nervous system. Neuroinflammation, modulated by glial cells, is a crucial event during the neurodegenerative process; consequently, there is an urgency to find new therapeutic products with anti-glioinflammatory properties. Five new furanocembranolides (1−5), along with leptolide, were isolated from two different extracts of Leptogorgia sp., and compound 6 was obtained from chemical transformation of leptolide. Their structures were determined based on spectroscopic evidence. These seven furanocembranolides were screened in vitro by measuring their ability to modulate interleukin-1β (IL-1β) production by microglial BV2 cells after LPS (lipopolysaccharide) stimulation. Leptolide and compounds 3, 4 and 6 exhibited clear anti-inflammatory effects on microglial cells, while compound 2 presented a pro-inflammatory outcome. The in vitro results prompted us to assess anti-glioinflammatory effects of leptolide in vivo in a high-fat diet-induced obese mouse model. Interestingly, leptolide treatment ameliorated both microgliosis and astrogliosis in this animal model. Taken together, our results reveal a promising direct biological effect of furanocembranolides on microglial cells as bioactive anti-inflammatory molecules. Among them, leptolide provides us a feasible therapeutic approach to treat neuroinflammation concomitant with metabolic impairment.
PB MDPI
SN 1660-3397
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/82930
UL https://uvadoc.uva.es/handle/10324/82930
LA eng
NO Marine Drugs, 2020, vol. 18, n. 8, p. 1-21.
NO Producción Científica
DS UVaDOC
RD 02-abr-2026