RT info:eu-repo/semantics/article
T1 Procalcitonin cannot be used as a biomarker of infection in heart surgery patients with acute kidney injury
A1 Heredia-Rodríguez, María
A1 Bustamante-Munguira, Juan
A1 Fierro, Inmaculada
A1 Lorenzo, Mario
A1 Jorge-Monjas, Pablo
A1 Gómez-Sánchez, Esther
A1 Álvarez, Francisco J.
A1 Bergese, Sergio D.
A1 Eiros, José María
A1 Bermejo-Martin, Jesús F.
A1 Gómez-Herreras, José I.
A1 Tamayo, Eduardo
K1 Acute Kidney Injury; Renal function failure; Infection; Cardiac surgery; Inflammatory response; Postoperative care
AB Purpose: We intended to assess how acute kidney injuy impacts on procalcitonin levels in cardiac surgery pa- tients, with or without infection, and whether procalcitonin might be used as a biomarker of infection in acute kidney injuy.Material and Methods: A case–control study was designed which included patients that had had cardiac surgery between January 2011 and January 2015. Every patient developing severe sepsis or septic shock (n = 122; 5.5%) was enrolled. In addition, consecutive cardiac surgery patients during 2013 developing systemic inflammatory response syndrome (n = 318) were enrolled. Those recruited 440 patients were divided into 2 groups, according to renal function.Results: Median procalcitonin levels were significantly higher during the 10 postoperative days in the acute kid- ney injury patients. Regression analysis showed that postoperatory day, creatinine, white blood cells and infec- tion were significantly (P b .0001) associated to serum procalcitonin level. In patients with creatinine ≥2, median procalcitonin levels were similar in infected and non-infected patients. Only when creatinine was less than 2 mg/L, the median procalcitonin levels were significantly higher in patients with infection, as compared to those with no infection.Conclusions: In acute kidney injuy patients, high procalcitonin levels are a marker of acute kidney injuy but will not be able to differentiate infected from non-infected patients.
PB W B SAUNDERS CO-ELSEVIER INC
SN 0883-9441
YR 2016
FD 2016
LK https://uvadoc.uva.es/handle/10324/83034
UL https://uvadoc.uva.es/handle/10324/83034
LA spa
NO J Crit Care, 2016 Jun:33:233-9
NO Producción Científica
DS UVaDOC
RD 24-feb-2026