RT info:eu-repo/semantics/article
T1 Development of a new polymeric formulation of rutin by supercritical antisolvent precipitation and evaluation of its nephroprotective capacity against cisplatin nephrotoxicity in rats
A1 Casanova, Alfredo Ginés
A1 Rodríguez Lucas, Lucía
A1 Pahino Villardón, Sara
A1 Giraldes Fernández, Iria Nerea
A1 Prieto, Marta
A1 Martín Martínez, Ángel
A1 Morales, Ana Isabel
K1 Rutin
K1 Nephroprotection
K1 Cisplatin
K1 Polymeric formulation
K1 Amorphous solid dispersion
K1 2302 Bioquímica
AB Nephrotoxicity associated with antitumor drugs such as cisplatin is a well-documented clinical challenge. The intrinsic toxicity of these drugs is driving the search for renoprotective strategies. Currently, one of the most popular is the use of natural substances with antioxidant properties, such as flavonoids. Rutin is a member of this family whose nephroprotective properties have already been studied. However, its bioavailability is very low due to its high lipophilicity. Polymeric nanoparticle design is one of the possible strategies used to solve pharmacokinetic problems. The aim of this work was to design and develop a new polymeric formulation of rutin and to evaluate its nephroprotective capacity against cisplatin toxicity in an experimental rat model. Rutin was processed and coated with Eudragit® polymers using the Supercritical Anti Solvent (SAS) process. A successful micronization and coating of rutin was achieved. In vitro release studies of the formulations obtained demonstrated that pure SAS-processed rutin showed a higher solubility and dissolution rate that unprocessed rutin, and that rutin coated with Eudragit® polymers combined this increased solubilization with a controlled release. However, after administration of the formulation with the best in vivo properties obtained in rats, they did not show a significant nephroprotective capacity. The histological study confirmed the negative results obtained in the functional study. Although this formulation did not show significant nephroprotective effects in vivo, the study provides valuable insights into the limitations of current polymeric encapsulation strategies for rutin.
PB Elsevier
SN 0896-8446
YR 2026
FD 2026
LK https://uvadoc.uva.es/handle/10324/83334
UL https://uvadoc.uva.es/handle/10324/83334
LA eng
NO The Journal of Supercritical Fluids, 2026, vol. 234, p. 106947
NO Producción Científica
DS UVaDOC
RD 06-mar-2026