RT info:eu-repo/semantics/article
T1 Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research
A1 Münch, Andreas
A1 Escudero Hernández, Celia
K1 Patología
K1 Inmunología
K1 Gastroenterología
K1 Biología celular
K1 Colitis colágena
K1 Genes HLA
K1 Inmunofisiopatología
K1 Enfermedad inflamatoria intestinal (EII)
K1 Colitis linfocítica
K1 Malabsorción
K1 Colitis microscópica
K1 Enfoques multiómicos
K1 Medicina de precisión
K1 2412 Inmunología
K1 3207 Patología
K1 3205.03 Gastroenterología
AB Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered osmoregulation. Conversely, lymphocytic colitis lacks genetic associations and displays a Th1/Th2 profile and paracellular/transcellular permeability. Lymphocytic colitis subclassifies into channelopathic lymphocytic colitis due to unique alteration of ion and organic acid transport that could result from drug exposure, and inflammatory lymphocytic colitis due to the involvement of moderate immune responses compared to collagenous colitis. As microscopic colitis mucosa remains intact and immune cells seem to stay inactive, microscopic colitis is an ideal model to explore early stages of IBD if collagenous colitis and lymphocytic colitis are studied as distinct entities. Exploiting multiomic approaches and established biobanks will ensure validation of microscopic colitis patient stratification, and deepening into pathomechanisms which could enable precision medicine.
PB Wiley
SN 2050-6406
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/83346
UL https://uvadoc.uva.es/handle/10324/83346
LA eng
NO United European Gastroenterology Journal, 2025, vol. 13, n. 8, p. 1367-1378.
NO Producción Científica
DS UVaDOC
RD 28-mar-2026