RT info:eu-repo/semantics/doctoralThesis
T1 Desarrollo de un modelo predictivo de riesgo de disfunción eréctil en varones con antecedente de COVID-19
A1 Natal Álvarez, Fernando
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Urología
K1 Erectile dysfunction
K1 Disfunción eréctil
K1 COVID-19
K1 COVID-19
K1 Cardiovascular diseases
K1 Enfermedades cardiovasculares
K1 Predictive models
K1 Modelos predictivos
K1 32 Ciencias Médicas
AB INTRODUCTIONCOVID-19 has been associated with erectile dysfunction. However, the durationof this impairment in erectile function following COVID-19 remains uncertain, with somesuggesting it could persist for up to one year post-COVID-19 infection. To date, nopredictive tool has been developed to assess the risk of developing erectile dysfunctionafter COVID-19. The aim of our work was to create a risk predictive model for erectiledysfunction one year after recovering from COVID-19.MATERIALS AND METHODSWe designed an observational prospective multicentre study. Participants wereclassified according to their COVID-19 history. The COVID-19 group (patients with a pasthistory of COVID-19) and the Control group (patients without a previous microbiologicaldiagnosis of COVID-19). A total of 361 patients (COVID-19 group, n =166; Control group,n=195) were assessed approximately 12 months following COVID-19 recovery. Theprimary outcome measure was erectile dysfunction, assessed using the 5-itemInternational Index of Erectile Function (IIEF-5). Additional data on epidemiologicvariables, comorbidities and active treatments were also collected. A binary logisticregression was applied to develop the risk predictive model. Among the modelsdeveloped, we selected the one with the higher Area Under the Curve (AUC). A test ofproportions was carried out to compare the erectile dysfunction rates differencebetween both groups.RESULTSThe median age was 55 years in both groups. Erectile dysfunction was present in55,9% of individuals in the COVID-19 group, compared to 44,1% in the Control group.The best predictive model for erectile dysfunction developed comprised 40 variablesand had an AUC of 0,75. The test of proportions confirmed a statistically significantdifference in the prevalence of erectile dysfunction between the two groups. The z-testvalue was -3,96 and the p value 7,4 x 10-5.CONCLUSIONThrough this study a risk predictive model for erectile dysfunction at 1 yearfollowing COVID-19 has been developed. The application of this tool could allow theearly identification of individuals at risk and avoid the unfavourable consequences oferectile dysfunction.
YR 2026
FD 2026
LK https://uvadoc.uva.es/handle/10324/83357
UL https://uvadoc.uva.es/handle/10324/83357
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 10-mar-2026