RT info:eu-repo/semantics/doctoralThesis
T1 Valoración neurocognitiva (experiencias anómalas del SELF) para la definición de grupos biológicamente válidos dentro de la esquizofrenia
A1 Hernández García, María Saray
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Esquizofrenia - Tratamiento
K1 Psychosis
K1 Esquizofrenia
K1 Self-experiences
K1 Biotipos
K1 3211 Psiquiatría
AB The general objective of this thesis was to study the differences in neurocognitive functions (anomalous self-experiences) in schizophrenia and to assess their neurobiological basis, evaluating their relationship with parameters previously associated with the definition of biologically relevant subgroups within the schizophrenia syndrome, thereby contributing to its characterization. To achieve this, three specific objectives were proposed: 1)To adapt and validate the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) from English into Spanish, enabling the assessment of psychosis-like anomalous self-experiences through a self-administered inventory; 2)To explore differences between segregated groups in terms of cognitive functions and clinical scores;3)To explore differences in cognitive functions between the segregated groups based on structural and functional connectivity variables, using global measures of brain network organization and modulation derived from graph theory.Taken together, the studies presented in this doctoral thesis have expanded the understanding of neurophysiological and neurocognitive alterations and the presence of ASEs (Anomalous Self-Experiences) in individuals with psychosis, contributing to the definition of biotypes within this syndrome. The results support the hypothesis that schizophrenia does not constitute a single clinical entity, but rather a set of diverse conditions that share certain clinical manifestations yet differ in their underlying mechanisms. In this context, new data-driven methodological approaches may emerge as more effective strategies to capture and understand the complexity and variability that characterize this mental disorder.
YR 2026
FD 2026
LK https://uvadoc.uva.es/handle/10324/83396
UL https://uvadoc.uva.es/handle/10324/83396
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 11-mar-2026