RT info:eu-repo/semantics/article
T1 Impact of Body Composition on Intraperitoneal Pressure and Ultrafiltration in Peritoneal Dialysis
A1 Sobrino Pérez, Alicia
A1 Pérez Escudero, Alfonso
A1 Sánchez García, Luisa
A1 Sanz Ballesteros, María Sandra
A1 Felipe Fernández, Carmen
A1 Hernández García, Esther
A1 Oviedo Gómez, Victoria
A1 Toro Casado, Raquel de
A1 Rodríguez Gómez, Astrid
A1 Fernández-Reyes Luis, María José
A1 Pérez Díaz, Vicente
K1 Nefrología
K1 Fisiología humana
K1 Bioquímica clínica
K1 Patología
K1 Bioimpedancia
K1 Presión intraperitoneal
K1 Ultrafiltración
K1 Acuaporinas
K1 Masa magra
K1 Masa grasa
K1 Ángulo de fase
K1 3205.06 Nefrología
K1 2410.10 Fisiología Humana
K1 3207 Patología
AB Introduction: An increase in body mass index (BMI) raises intraperitoneal pressure (IPP), which in turn counteracts ultrafiltration (UF). However, BMI is not directly associated with UF, contrary to what might be expected. We examined these relationships in greater depth by breaking down BMI into fat tissue index (FTI), lean tissue index (LTI), and overhydration (OHI), assessed by bioimpedance spectroscopy (BIS). Methods: Two peritoneal equilibration tests (PETs) using 4.25%/3.86% dextrose (2 L and 1 L fill volumes) were performed in 76 unselected patients. IPP was measured repeatedly and BIS was conducted to calculate LTI, FTI, OHI and phase angle at 50 kHz (PhA). Results: IPP increased with intraperitoneal volume (empty: 7.8 cmH₂O; 1 L: 10.3 cmH₂O; 2 L: 12.2 cmH₂O) and correlated negatively with UF. BMI correlated positively with IPP but not with UF. FTI correlated positively with BMI and IPP and negatively with UF. LTI did not correlate with BMI or IPP but correlated positively with UF. These relationships were mirrored in aquaporinmediated free water transport (FWT). PhA mirrored LTI. Conclusions: The effects of BMI on IPP and of IPP on UF appear to be mediated by FTI, whereas LTI independently enhances UF. Aquaporin-mediated FWT shows similar associations. Routine assessment of IPP and body composition may help identify patients at higher risk for IPP-related UF impairment.
YR 2026
FD 2026
LK https://uvadoc.uva.es/handle/10324/83416
UL https://uvadoc.uva.es/handle/10324/83416
LA eng
NO Preprint
NO Producción Científica
DS UVaDOC
RD 05-abr-2026