RT info:eu-repo/semantics/article
T1 Interplay Between Fibroblast Growth Factor-19, Beta-Klotho, and Receptors Impacts Cardiovascular Risk in Chronic Kidney Disease
A1 González-Rodríguez, Laura
A1 Martí-Antonio, Manuel
A1 Díaz-Acevedo, Virginia
A1 Mota-Zamorano, Sonia
A1 Chicharro, Celia
A1 Cancho, Bárbara
A1 Gil-Lozano, Raquel
A1 Bandrés, Fernando
A1 Robles, Nicolás R.
A1 Gervasini, Guillermo
AB Background: Chronic kidney disease (CKD) markedly increases the risk of cardiovascular events (CVE), yet conventional biomarkers often fail to capture this excess risk. We evaluated whether circulating levels and genetic variability within the FGF19/β-Klotho/FGFR axis contribute to CV risk stratification in CKD. Methods: In 579 CKD patients, plasma FGF19 and β-Klotho concentrations were quantified, and 64 genetic variants across FGF19, KLB, FGFR1, and FGFR4 genes were analyzed. Results: Cluster analysis identified three distinct biomarker profiles, with one cluster—characterized by low/intermediate FGF19 and markedly elevated β-Klotho—showing significantly reduced CV event-free survival. After adjustment for clinical covariates, this cluster was independently associated with higher CV risk [HR = 2.97 (1.12–7.92), p = 0.029]. Two genetic variants also showed independent associations: FGFR1 rs2288696 (protective) [HR = 0.51 (0.27–0.95), p = 0.029] and KLB rs2687971 (risk-increasing) [HR = 2.03 (0.97–4.27), p = 0.046]. A combined CV risk model incorporating biomarker clusters, relevant SNPs, and traditional risk factors achieved good discriminative ability (C-index = 0.80), with the FGF19/β-Klotho cluster showing predictive importance comparable to diabetes and previous CV history. Conclusions: These results indicate that integrating FGF19-Klotho biomarkers with genetic information may improve CV risk prediction in CKD.
PB MDPI
YR 2026
FD 2026-01-27
LK https://uvadoc.uva.es/handle/10324/83940
UL https://uvadoc.uva.es/handle/10324/83940
LA eng
NO J. Clin. Med. 2026, 15(3), 1005
NO Producción Científica
DS UVaDOC
RD 08-abr-2026