RT info:eu-repo/semantics/article
T1 Benzodiazepine use and risk of dementia: prospective population based study
A1 Billiot ide Gage, Sophie
A1 Bégaud, Bernard
A1 Bazin, Fabienne
A1 Verdoux, Hélène
A1 Dartigues, Jean-François
A1 Pérès, Karine
A1 Kurth, Tobias
A1 Pariente, Antoine
A1 Carvajal García-Pando, Alfonso
K1 Benzodiazepinas
AB Objective To evaluate the association between use of benzodiazepinesand incident dementia.Design Prospective, population based study.Setting PAQUID study, France.Participants 1063 men and women (mean age 78.2 years) who werefree of dementia and did not start taking benzodiazepines until at leastthe third year of follow-up.Main outcome measures Incident dementia, confirmed by a neurologist.Results During a 15 year follow-up, 253 incident cases of dementiawere confirmed. New use of benzodiazepines was associated with anincreased risk of dementia (multivariable adjusted hazard ratio 1.60,95% confidence interval 1.08 to 2.38). Sensitivity analysis consideringthe existence of depressive symptoms showed a similar association(hazard ratio 1.62, 1.08 to 2.43). A secondary analysis pooled cohortsof participants who started benzodiazepines during follow-up andevaluated the association with incident dementia. The pooled hazardratio across the five cohorts of new benzodiazepine users was 1.46 (1.10to 1.94). Results of a complementary nested case-control study showedthat ever use of benzodiazepines was associated with an approximately50% increase in the risk of dementia (adjusted odds ratio 1.55, 1.24 to1.95) compared with never users. The results were similar in past users(odds ratio 1.56, 1.23 to 1.98) and recent users (1.48, 0.83 to 2.63) butreached significance only for past users.Conclusions In this prospective population based study, new use ofbenzodiazepines was associated with increased risk of dementia. Theresult was robust in pooled analyses across cohorts of new users ofbenzodiazepines throughout the study and in a complementarycase-control study. Considering the extent to which benzodiazepinesare prescribed and the number of potential adverse effects of this drugclass in the general population, indiscriminate widespread use shouldbe cautioned against.
PB BMJ Publishing Group
SN 0959-8138
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/8596
UL http://uvadoc.uva.es/handle/10324/8596
LA eng
NO BMJ 2012;345:e6231
NO Producción Científica
DS UVaDOC
RD 22-nov-2024