RT info:eu-repo/semantics/article
T1 EUDRAGENE: European collaboration to establish a case–control DNA collection for studying the genetic basis of adverse drug reactions
A1 Molokhia, Mariam
A1 McKeigue, Paul
K1 Medicamentos - Efectos adversos
AB Type B adverse drug reactions (ADRs) are often serious, limit the usefulness of drugs that are otherwise effective, and increase the risks of drug development as they often lead to postmarketing withdrawal. There is evidence that susceptibility to at least some Type B ADRs is under strong genetic influence. Identifying genes in which variation influences susceptibility has obvious practical value for genetic testing and might also make it easier to screen molecules likely to cause ADRs at an early stage of the drug development process. Research in this area is hampered by the lack of a resource in which to study genetic determinants of susceptibility to Type B ADRs. As serious Type B ADRs are rare, case-control designs are the most frequently-used approach. The EUDRAGENE collaboration seeks to develop a resource using an international collaboration. This will provide a basis for adverse drug susceptibility genome association-wide studies using tag single nucleotide polymorphisms, or a direct approach using putative functional polymorphisms.
PB Future Medicine
SN 1462-2416
YR 2006
FD 2006
LK http://uvadoc.uva.es/handle/10324/9060
UL http://uvadoc.uva.es/handle/10324/9060
LA eng
NO Pharmacogenomics. 2006 Jun;7(4):633-8.
NO Producción Científica
DS UVaDOC
RD 22-nov-2024