TY - JOUR AU - Villa Pérez, Pablo AU - Merino Antolín, Beatriz AU - Fernández Díaz, Cristina María AU - Cidad Velasco, María del Pilar AU - Domínguez Lobatón, María Carmen AU - Moreno Díaz-Calderón, Alfredo AU - Muturi, Harrison T. AU - Ghadieh, Hilda E. AU - Leissring, Malcolm A. AU - Cózar Castellano, Irene AU - Perdomo Hernández, Germán PY - 2018 SN - 0026-0495 UR - http://uvadoc.uva.es/handle/10324/44474 AB - The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define... LA - eng PB - Elsevier KW - Insulin-degrading enzymes KW - Encimas degradadoras de insulina KW - Insulin receptors KW - Receptores de insulina TI - Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice DO - 10.1016/j.metabol.2018.08.001 ER -