TY  - JOUR 
AU  - Corraliza Gómez, Miriam
AU  - Lillo, Concepción
AU  - Cózar Castellano, Irene
AU  - Arranz Sanz, Eduardo
AU  - Sánchez Romero, Diego
AU  - Ganfornina Álvarez, María Dolores
PY  - 2022
SN  - 2073-4409
UR  - https://uvadoc.uva.es/handle/10324/62942
AB  - The insulin-degrading enzyme (IDE) is a zinc-dependent metalloendopeptidase that belongs to the M16A metalloprotease family. IDE is markedly expressed in the brain, where it is particularly relevant due to its in vitro amyloid beta (Aβ)-degrading...
LA  - eng
PB  - MDPI
KW  - Insulin-degrading enzyme
KW  - Phylogeny
KW  - Filogenia
KW  - Molecular evolution
KW  - Genetics
KW  - Genetica
KW  - Microglia
KW  - Lipids
KW  - Lípidos
KW  - Extracellular vesicles
KW  - Inflammation
KW  - Inflamación
KW  - Amyloid
KW  - Amiloides
KW  - Oxidative stress
KW  - Estrés oxidativo
KW  - Biochemistry
KW  - Molecular biology
TI  - Evolutionary origin of insulin-degrading enzyme and Its subcellular localization and secretion mechanism: A study in microglial cells
DO  - 10.3390/cells11020227
ER  -