TY - JOUR AU - Fu, Guo AU - Casas, Javier AU - Rigaud, Stephanie AU - Rybakin, Vasily AU - Lambolez, Florence AU - Brzostek, Joanna AU - Hoerter, John A. H. AU - Paster, Wolfgang AU - Acuto, Oreste AU - Cheroutre, Hilde AU - Sauer, Karsten AU - Gascoigne, Nicholas R. J. PY - 2013 SN - 0028-0836 UR - https://uvadoc.uva.es/handle/10324/64300 AB - This work shows that the Themis protein has a critical role in positive and negative thymocyte selection by dampening responses to low-affinity ligands but without affecting responses to high-affinity ligands, thus enabling positive selection of... LA - eng TI - Themis sets the signal threshold for positive and negative selection in T-cell development DO - 10.1038/nature12718 ER -