TY - JOUR AU - Fernández Díaz, Cristina María AU - Merino Antolín, Beatriz AU - López Acosta, José Francisco AU - Cidad Velasco, María Del Pilar AU - Fuente García, Miguel Ángel de la AU - Domínguez Lobatón, María Carmen AU - Moreno Díaz-Calderón, Alfredo AU - Leissring, Malcolm A. AU - Perdomo, Germán AU - Cózar Castellano, Irene PY - 2019 SN - 0193-1849 UR - https://uvadoc.uva.es/handle/10324/74563 AB - Inhibition of insulin-degrading enzyme (IDE) has been proposed as a possible therapeutic target for type 2 diabetes treatment. However, many aspects of IDE's role in glucose homeostasis need to be clarified. In light of this, new preclinical models... LA - spa TI - Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity DO - 10.1152/ajpendo.00040.2019 ER -