TY - JOUR AU - Meana González, Clara AU - San José Rodríguez, Gonzalo AU - Balboa García, María Ángeles AU - Casas Requena, Javier PY - 2026 SN - 1420-682X UR - https://uvadoc.uva.es/handle/10324/84318 AB - T cell receptor (TCR) signaling is critically dependent on the Src-family kinase Lck, whose activation is tightly regulated both spatially and conformationally during antigen recognition. Here, we employ an improved second-generation FRET-based... LA - eng PB - Springer Nature KW - Biología molecular KW - Biofísica KW - Bioquímica KW - CD8 KW - TCR KW - LCK KW - Immune Synapse KW - FRET KW - Spatial Regulation TI - Spatial regulation of Lck activation at the CD8 immune synapse revealed by a FRET-Based biosensor DO - 10.1007/s00018-026-06209-x ER -