TY - JOUR AU - Merino Antolín, Beatriz AU - Casanueva Álvarez, Elena AU - Quesada, Iván AU - González Casimiro, Carlos Manuel AU - Fernández Díaz, Cristina María AU - Postigo Casado, Tamara AU - Leissring, Malcolm A. AU - Kaestner, Klaus H. AU - Perdomo Hernández, Germán AU - Cózar Castellano, Irene PY - 2022 SN - 0012-186X UR - https://uvadoc.uva.es/handle/10324/53866 AB - Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme... LA - eng PB - Springer KW - Alpha cells KW - Cytoskeleton KW - Hyperglucagonaemia KW - Insulin-degrading enzyme KW - Primary cilia KW - Proliferation KW - Type 2 diabetes TI - Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation DO - 10.1007/s00125-022-05729-y ER -