TY  - JOUR 
AU  - Corraliza Gómez, Miriam
AU  - Bermejo Pastor, Teresa
AU  - Lilue, Jingtao
AU  - Rodriguez Iglesias, Noelia
AU  - Valero Gómez Lobo, Jorge
AU  - Cózar Castellano, Irene
AU  - Arranz Sanz, Eduardo
AU  - Sánchez Romero, Diego
AU  - Ganfornina Álvarez, María Dolores
PY  - 2023
SN  - 1742-2094
UR  - https://uvadoc.uva.es/handle/10324/82941
AB  - The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is able to cleave many substrates in vitro,...
LA  - eng
PB  - Springer Nature
KW  - Bioquímica
KW  - Gerontología
KW  - Neurobiología
KW  - Enfermedades del sistema nervioso
KW  - Enzima degradadora de insulina
KW  - Microglía
KW  - Fagocitosis de mielina
KW  - Endocitosis de beta-amiloide
KW  - Inflamación
KW  - Estrés oxidativo
KW  - Proliferación microglial
KW  - Secreción de citocinas
TI  - Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
DO  - 10.1186/s12974-023-02914-7
ER  -