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Título
WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation
Autor
Año del Documento
2002
Editorial
Elsevier (Cell Press)
Descripción
Producción Científica
Documento Fuente
Immunity, 2002, 16(2):193-204
Résumé
WIP stabilizes actin filaments and is important for filopodium formation. To define the role of WIP in immunity, we generated WIP-deficient mice. WIP(minus sign/minus sign) mice have normal lymphocyte development, but their T cells fail to proliferate, secrete IL-2, increase their F-actin content, polarize and extend protrusions following T cell receptor ligation, and are deficient in conjugate formation with superantigen-presenting B cells and anti-CD3 bilayers. In contrast, WIP-deficient B lymphocytes have enhanced proliferation and CD69 expression following B cell receptor ligation and mount normal antibody responses to T-independent antigens. Both WIP-deficient T and B cells show a profound defect in their subcortical actin filament networks. These results suggest that WIP is important for immunologic synapse formation and T cell activation.
Materias (normalizadas)
Biología celular
ISSN
1074-7613
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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