Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/21846
Título
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system.
Autor
Año del Documento
2015
Editorial
Nature Publishing Group
Descripción
Producción Científica
Documento Fuente
Nature Chemistry, 2015, vol. 7, p. 897–904
Zusammenfassung
Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non- equilibrium for substantial periods of time. The system enables the formation of a robust membrane that displays controlled assembly and disassembly capabilities, adhesion and sealing to surfaces, self-healing and the capability to undergo morphogenesis into tubular structures with high spatiotemporal control. We use advanced microscopy along with turbidity and spectroscopic measurements to investigate the mechanism of assembly and its relation to the distinctive membrane architecture and the resulting dynamic properties. Using cell-culture experiments with endothelial and adipose- derived stem cells, we demonstrate the potential of this system to generate complex bioactive scaffolds for applications such as tissue engineering.
Materias (normalizadas)
Moléculas - Propiedades
ISSN
ISSN: 1755-4330
Revisión por pares
SI
Patrocinador
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
Version del Editor
Idioma
spa
Derechos
openAccess
Aparece en las colecciones
Dateien zu dieser Ressource
![Attribution-NonCommercial-NoDerivatives 4.0 International](/themes/Mirage2//images/creativecommons/cc-by-nc-nd.png)