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Título
The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal
Autor
Año del Documento
2016
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Epilepsy Behavior
Abstract
GASH:Sal hamster strain and the control Syrian hamsters.
The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic–clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem.
The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.
Palabras Clave
Epilepsia audiogénica
AFLP
Hamsters
Revisión por pares
SI
Propietario de los Derechos
Elsevier
Idioma
eng
Derechos
openAccess
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