Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/31622
Título
Evaluation of the role of Meis 2 during inner ear formation and morphogenesis
Autor
Director o Tutor
Año del Documento
2018
Titulación
Máster en Investigación Biomédica
Abstract
Meis genes are vertebrate orthologues of the Drosophila homolog homothorax (hth) gene
which encode for transcription factors belonging to a subfamily of TALE proteins. In
mammals, TALE superclass comprises two families: PBC (Pbx1-4 genes) and MEINOX,
this latter including the PREP (Prep1-2 genes) and MEIS (Meis1-3 genes) sub-families
(Schulte, 2014).
TALE (Three Aminoacid Loop Extension) proteins receive their name from the shared
feature of a proline-tyrosine-proline motive insertion between the first and second helix of
the highly conserved helix-loop-helix homeodomain. (Longobardi et al., 2014) This
homeodomain is around 60 amino acids long and allows TALE proteins to bind to DNA,
thus conferring them the ability to act as transcription factors. (Mukherjee and Bürglin,
2007). Additionally, these proteins contain protein-protein interaction domains in their
amino-terminal regions that permit them to form complexes with other transcription
factors.
While the homeodomain is conserved throughout the members of the TALE class, these
amino-terminus regions are family specific: PBX family possess PBC-A and PBC-B
domains while the MEIS-A and MEIS-B domains are present in the PREP and MEIS
subfamilies
Palabras Clave
Meis 2
Morfogénesis
Idioma
spa
Derechos
openAccess
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- Trabajos Fin de Máster UVa [6334]
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