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Título
Synthesis of Enantiopure Oxygen- and Nitrogen-Containing Heterocycles by Diastereoselective Ring-Closing Metathesis Reaction in Perhydro-1,3-benzoxazine Derivatives
Autor
Año del Documento
2019
Editorial
Wiley
Descripción
Producción Científica
Documento Fuente
Advanced Synthesis and Catalysis, Volume361, Issue 5, 2019 Pages 1042-1063
Abstract
Diastereoselective ring‐closing metathesis reactions on chiral trienic perhydro‐1,3‐benzoxazines derived from (−)‐8‐aminomenthol featuring two diastereotopic olefin chains is described. The diastereochemical outcome of the cyclization appeared to be dependent on the length and position of the olefin chains in perhydro‐1,3‐benzoxazine, the degree of substitution of the double bonds and the ruthenium catalyst used. After separation of the diastereomers, and removal of the chiral auxiliary, enantiopure oxygen‐ and nitrogen‐containing heterocycles were obtained.
Palabras Clave
Síntesis asimétrica
Metátesis
Asymmetric synthesis
Metathesis
ISSN
1615-4150
Revisión por pares
SI
Patrocinador
Ministerio de Economía, Industria y Competitividad (Project FEDER-CTQ2014-59870-P)
Junta de Castilla y León (Ref. Project FEDER-VA115P17)
Junta de Castilla y León (Ref. Project FEDER-VA115P17)
Version del Editor
Propietario de los Derechos
© 2019 Wiley
Idioma
eng
Tipo de versión
info:eu-repo/semantics/acceptedVersion
Derechos
openAccess
Collections
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