Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms

Treviño, Ana; Lopez, Mariola; Vispo, Eugenia; Aguilera, Antonio; Ramos, José M; Benito, Rafael; Roc, Lourdes; Eiros Bouza, José María; Mendoza, Carmen de; Soriano, Vincent

doi:10.1093/cid/cis343

Título

Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms

dc.contributor.author	Treviño, Ana
dc.contributor.author	Lopez, Mariola
dc.contributor.author	Vispo, Eugenia
dc.contributor.author	Aguilera, Antonio
dc.contributor.author	Ramos, José M
dc.contributor.author	Benito, Rafael
dc.contributor.author	Roc, Lourdes
dc.contributor.author	Eiros Bouza, José María
dc.contributor.author	Mendoza, Carmen de
dc.contributor.author	Soriano, Vincent
dc.date.accessioned	2021-02-24T16:02:07Z
dc.date.available	2021-02-24T16:02:07Z
dc.date.issued	2012
dc.identifier.citation	Clinical Infectious Diseases, 2012, vol. 55, n. 1, p. e1-e4	es
dc.identifier.issn	1058-4838	es
dc.identifier.uri	http://uvadoc.uva.es/handle/10324/45386
dc.description	Producción Científica	es
dc.description.abstract	Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B testing and closer follow-up of HTLV-1 asymptomatic CT/TT carriers is warranted.	es
dc.format.mimetype	application/pdf	es
dc.language.iso	eng	es
dc.publisher	Oxford University Press	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.classification	Alelos polimorfismo	es
dc.subject.classification	Virus	es
dc.subject.classification	Médula espinal	es
dc.title	Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms	es
dc.type	info:eu-repo/semantics/article	es
dc.rights.holder	© Oxford University Press	es
dc.identifier.doi	10.1093/cid/cis343	es
dc.relation.publisherversion	https://academic.oup.com/cid/article/55/1/e1/318542	es
dc.identifier.publicationfirstpage	e1	es
dc.identifier.publicationissue	1	es
dc.identifier.publicationlastpage	e4	es
dc.identifier.publicationtitle	Clinical Infectious Diseases	es
dc.identifier.publicationvolume	55	es
dc.peerreviewed	SI	es
dc.description.project	Fundación Investigación y Educación en Sida Grant (IES) FIS (CP05/00300)	es
dc.description.project	Red de Investigación en SIDA Grant (RIS, ISCIII-RETIC RD06/006)	es
dc.description.project	Proyecto europeo NEAT Grant (LSHP-CT-2006-037570)	es
dc.identifier.essn	1537-6591	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.type.hasVersion	info:eu-repo/semantics/publishedVersion	es
dc.subject.unesco	32 Ciencias Médicas	es

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