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Título
Voltammetric study of triazole antifungal agent terconazole on sp3 and sp2 carbon-based electrode materials
Autor
Año del Documento
2020
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Journal of Electroanalytical Chemistry, 2020, vol. 863, p. 114054
Abstract
Terconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in its molecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L−1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 μmol L−1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD ~ 4%) and detection limits reaching 0.50 μmol L−1 and 1.23 μmol L−1, respectively.
Materias Unesco
23 Química
24 Ciencias de la Vida
Palabras Clave
Voltamétrico
Terconazol
ISSN
1572-6657
Revisión por pares
SI
Patrocinador
Czech Science Foundation (project 18-01710S) and carried out within the framework of Specific University Research (SVV 260440)
Junta de Castilla y León y EU-FEDER (CLU 2017-09)
Junta de Castilla y León y EU-FEDER (CLU 2017-09)
Version del Editor
Propietario de los Derechos
© 2020 Elsevier
Idioma
eng
Tipo de versión
info:eu-repo/semantics/acceptedVersion
Derechos
openAccess
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