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Título
Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
Autor
Año del Documento
2000
Editorial
American Society for Microbiology
Descripción
Producción Científica
Documento Fuente
Infection and Immunity, 2000, vol 68, n. 3, p. 1740-1745
Abstract
Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the
production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of production
of NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) was
confirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observations
might help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septic
shock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans.
Materias Unesco
24 Ciencias de la Vida
Palabras Clave
Lipopolisacáridos
Lipopolysaccharides
Brucella abortus
Brucella melitensis
Macrófagos
Macrophages
ISSN
0019-9567
Revisión por pares
SI
Patrocinador
This work was supported by (grants FIS 96/1017, SAF96-0144, and SAF98-0176)
Version del Editor
Propietario de los Derechos
© 2000 American Society for Microbiology
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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