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Título
Impact on outcomes across KDIGO-2012 AKI criteria according to baseline renal function
Autor
Año del Documento
2019
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Journal of Clinical Medicine (JCM), 2019, vol. 8, n. 9, 1323
Abstract
Acute kidney injury (AKI) and Chronic Kidney Disease (CKD) are global health problems. The pathophysiology of acute-on-chronic kidney disease (AoCKD) is not well understood. We aimed to study clinical outcomes in patients with previous normal (pure acute kidney injury; P-AKI) or impaired kidney function (AoCKD) across the 2012 Kidney Disease Improving Global Outcomes (KDIGO) AKI classification. We performed a retrospective study of patients with AKI, divided into P-AKI and AoCKD groups, evaluating clinical and epidemiological features, distribution across KDIGO-2012 criteria, in-hospital mortality and need for dialysis. One thousand, two hundred and sixty-nine subjects were included. AoCKD individuals were older and had higher comorbidity. P-AKI individuals fulfilled more often the serum creatinine (SCr) > 3.0x criterion in AKI-Stage3, AoCKD subjects reached SCr > 4.0 mg/dL criterion more frequently. AKI severity was associated with in-hospital mortality independently of baseline renal function. AoCKD subjects presented higher mortality when fulfilling AKI-Stage1 criteria or SCr > 3.0x criterion within AKI-Stage3. The relationship between mortality and associated risk factors, such as the net increase of SCr or AoCKD status, fluctuated depending on AKI stage and stage criteria sub-strata. AoCKD patients that fulfil SCr increment rate criteria may be exposed to more severe insults, possibly explaining the higher mortality. AoCKD may constitute a unique clinical syndrome. Adequate staging criteria may help prompt diagnosis and administration of appropriate therapy.
Materias (normalizadas)
Riñones - Enfermedades
Chronic renal failure
Insuficiencia renal crónica
Materias Unesco
3205.06 Nefrología
ISSN
2077-0383
Revisión por pares
SI
Version del Editor
Propietario de los Derechos
© 2019 MDPI
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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