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Título
Aptamer-functionalized natural protein-based polymers as innovative biomaterials
Autor
Año del Documento
2020
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Pharmaceutics, 2020, Vol.12, Nº. 11, 1115
Zusammenfassung
Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell–material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems.
Materias (normalizadas)
Biomaterials
Biomedicina
Biopolymers
Polymers in medicine
Materias Unesco
2403 Bioquímica
2302.21 Biología Molecular
Palabras Clave
Aptamers
ISSN
1999-4923
Revisión por pares
SI
Patrocinador
Ministerio de Economía, Industria y Competitividad - Fondo Europeo de Desarrollo Regional - Fondo Social Europeo (Proyects MAT2016-79435-R, DTS19/00162, and PID2019-106386RB-I00)
Junta de Castilla y León (Project VA317P18)
Junta de Castilla y León (Project VA317P18)
Version del Editor
Propietario de los Derechos
© 2020 The Authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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