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Título
Clinical profile, treatment and predictors during the first COVID-19 wave: a population-based registry analysis from Castile and Leon hospitals
Autor
Año del Documento
2020
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
International Journal of Environmental Research and Public Health. 2020, Vol.17, Nº. 24, 9360
Résumé
The first wave of the COVID-19 pandemic collapsed the hospitals in Castile and Leon (Spain). An analysis of the clinical characteristics, drug therapies and principal outcome predictors in the COVID-19 hospitalized patients from 1 March to 31 May 2020 is presented through a population-based registry study. Hospital stay variables, ventilation mode data and clinical outcomes were observed. In Castile and Leon hospitals, 7307 COVID-19 patients were admitted, with 57.05% being male and a median of 76 years. The mortality rate was 24.43%, with a high incidence of severe acute respiratory syndrome (SARS) (14.03%) and acute kidney injury (AKI) (10.87%). The most used medicines were antibiotics (90.83%), antimalarials (42.63%), steroids (44.37%) and antivirals, such as lopinavir/ritonavir (42.63%). The use of tocilizumab (9.37%) and anti-SIRS (systemic inflammatory response syndrome) medicines (7.34%) were remarkable. Fundamentally, death occurred more likely over 65 years of age (OR: 9.05). In addition, the need for ventilation was associated with a higher probability of death (OR: 3.59), SARS (OR: 5.14) and AKI (OR: 2.31). The drug-use pattern had been modified throughout the COVID-19 first wave. Multiple factors, such as age, gender and the need for mechanical ventilation, were related to the worst evolution prognosis of the disease.
Materias (normalizadas)
SARS (Disease)
COVID-19
Enfermedades por virus - Tratamiento
Mortalidad
Novel respiritory viral diseases
Nephrology
Riñones - Enfermedades
Materias Unesco
2420 Virología
ISSN
1660-4601
Revisión por pares
SI
Patrocinador
Gerencia Regional de Salud - (Proyecto GRS COVID 10/A/20)
Version del Editor
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Aparece en las colecciones
Fichier(s) constituant ce document
Tamaño:
958.3Ko
Formato:
Adobe PDF
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